The most improbable thing has happened: my adult stem cells have been regenerated. Several subsets of the stem cells have produced observable consequences. New body hair has grown from the tops of my toes to my eyebrows. And my eyelashes hit my glasses now. My fingernails are thicker, so are my toenails. My dry mouth is gone and the saliva glands keep saliva flowing without direct food stimulation. My dry eyes are no longer dry, tear glands are keeping a flow of tears going.
My erectile dysfunction has lessened: I have had erections when I didn't have any for 7 years. Obviously the gonads are, to some extent, regenerated. These are observable facts.
Inferences can be directly drawn on several other sets of stem cells being regenerated. My urine flow is a greater average volume and is expelled with greater pressure. My feces appears more as long tapered cylinders than at any time in my memory. And the force required to push the feces out is much less. These last two observations have led me to believe that the muscles of my bladder wall have been supplemented with new muscle cells and that the muscle cells in the walls of my large intestine have been supplemented. I started getting mucosal prolapse, where the lining of lower rectum protrudes from the anus. In about 7 or 8 months after my stem cells regenerated the lining withdrew back into my rectum. I firmly believe none of these conditions have ever been rejuvenated or fixed without surgery in all the history of medicine. Of course erectile dysfunction has been 'treated', as has dry mouth and dry eyes, but never made 'normal' as after adolescence.
Guesses, which are not reliable, supplement my personal conclusion of my stem cells being stimulated. I believe new neurons are being generated and others are rejuvenated. At the beginning of my observations reported above I also noticed early morning clear nasal efflux. I interpreted this as waste from neuron generation.
Feelings, which are also not reliable, add to my belief: I believe I wake more refreshed than previously. That my muscles are tighter and “push me to exercise”. I believe my memory is improving: when I wake my “to-do” list has returned and I “know” that I must take my medicine, get a shower, put on fresh clothes, make and eat breakfast, etc. And I do. Recall seems better but more importantly I am again “recording” most of the information that I receive. And autonomic actions like not walking into a wall when my head is turned, not getting a good grip on a glass or cup and spilling things, knowing where my body parts are without conscious attention, “having my mind together” appears much better.
Hope is not reliable. But I hope, and tend to believe, that my stem cells in the heart, lungs, kidneys, liver, bones, etc. have also been regenerated. I hope the new stem cells are producing daughter cells that replace senescent and damaged cells of the local tissue and organs. The evidence simply isn't in yet.
I look, feel, and see that I am healthier. And it is all improbable, very improbable.


                                                                                  What's Going On ?

                                                      The Adult Stem Cell Regeneration (ASCR) Hypothesis


        There may be a need to change the “growth” paradigm of biology. Cell division is described as mitosis and meiosis, (Watson p. 5, 6; Sadava p. 208 et. seg.; Campbell, p. 217) Mitosis is a process of the cell duplicating all its internal structure and content and then wrapping the cell wall around the internally separated cell structures and finally dividing them completely, resulting in two nearly identical cells. Where there had been one there are now two, working, functioning, growing, alive cells. Meiosis is the process of making a cell with only one set of chromosomes instead of the normal two sets created in mitosis. This occurs when sex is the reproductive norm of the given organism. Prior to mating, the germ cells of the life forms are prepared for sexual fertilization by the meiosis process and each germ cell carries one set of chromosomes which combine together making the double set of chromosomes for the inherited DNA of the particular species..
        Simple observation of the growth of many celled plants and animals shows that there are more than two types of cells generated in the life of such life forms. Mitosis can only result in identical single celled creatures. Multi-celled creatures must have a different process. Biology has shown the process by which the wide variety of body cells are grown is stem cell production of a new stem cell and a new 'tissue cell', frequently called a 'daughter cell', Watson, p 763; Sadava, 408. The division of a stem cell is not mitotic, it does not produce two identical cells, it produces one cell that is closely identical to the initial stem cell and one that is a tissue cell often much different than the original stem cell.
This is important because the replacement of dead, dying, or senescent stem cells with fresh newly born ones adds health, and probably years, to all and any tissues. It appears that senescent or damaged adult stem cells are a starting point for tissue failure and then organ degradation with death as the final result.
        The reaction to these facts appears simple: regenerate the adult stem cells by stimulating their niches, that is, mTor, wnt, lgr5 and other stem cells in the various niches, and their mechanistic pathways so that a youthful percentage of tissue cells result and the organ homeostasis is maintained day after day, month after month and year after year.
        Pterostilbene probably acts as a regeneration signal to mtor in the niche (1) by blocking the mtor signal that turns off, or down, the contact with wnt. The mtor signal represses wnt signaling and pterostilbene reduces the repression. Wnt then signals LGR5 or other stem cells to start a new cell cycle of growth or to awaken their senescent cell cycles which results in new, or regenerated, stem cells and new tissue cells. This wnt signal is heavily dependent on a high concentration of Cysteine. Adolesce supplies the cysteine by way of NAC, n-acetylcysteine.  But the signal needs to find cells with energy and enzymes and co-enzymes, such as vitamins (2), ready to take part in the making of new protein and ultimately new cells with new mitochondria generating the ATP chemical energy, aided by the NAD+ precursors of nicotinamide roboside (vitamin b3) which Adolesce also presents. We believe there is mtor signaling dampened by pterostelbene permitting wnt action. Adolesce presents the niche with Cysteine, via N-Acetylcysteine, B vitamins necessary to support the making of new protein (vitamins b9 and b12, both necessary for the creation of RNA and DNA) all  resulting in either two stem cells from the one regenerated stem cell, or a new stem cell and a new tissue cell depending on which path the regenerated stem cell takes.

Adult Stem Cell Regeneration LLC
P.O. Box 1603
South Hackensack, NJ 07606
551-255-7555


Watson et.al Molecular Biology of the Gene, 1987, Benjamin/Cummings
Sadava, et. al. Life, The Science of Biology, 2014, Sinauer Associates
Biology, Campbell and Reece, 2002, Benjamin Cummings

1.Growth Signaling at the Nexus of Stem Cell Life and Death, Kris C. Wood and David M. Sabatini

   Cell Stem Cell 5, September 4, 2009

2. Mild Depletion of Dietary Folate Combined with Other B Vitamins Alters Multiple Components of the    Wnt Pathway in Mouse Colon; Zhenhua Liu Sang-Woon Choi, et al.
   The Journal of Nutrition, Volume 137, Issue 12, 1 December 2007, Pages 2701